POWER OF THE PLACENTA

Unlocking health Benefits today — and potentially tomorrow

Placental blood and tissue are significant sources of stem cells that are more versatile than the stem cells found in cord blood. Placental stem cells can increase the chances of transplant success today and possibly emerge as treatments for other diseases in the future. Here is more information about the benefits of placental blood and tissue banking in addition to cord blood banking.

Bank More Potentially Life-Saving Stem Cells

1. Maximize the Number of Stem Cells Collected

When banking cord blood alone, a typical collection will yield 1.8 million CD34+ stem cells.1 Having a high number of CD34+ stem cells in your collection is important because these cells indicate how likely it is that the collection can be transplanted successfully. However, a study found that the placenta contains 10 times more CD34+ stem cells than the average cord blood collection.2 Therefore, stem cells from the placental blood and tissue can increase the number of CD34+ stem cells in your banked collection.3

2. More Cells Can Lead to Better Transplant Outcomes

If you need to use your collection for a transplant, numerous studies have shown that using more stem cells may improve survival in transplant patients.4,5 Placental banking can yield high quantities of CD34+ cells that may improve transplant success.3

Lifebank® began providing families with placental banking in 2006, so you can enjoy peace of mind with the knowledge that you are banking with an experienced placental bank.6  You can also click here to hear Quentin’s story. He is the recipient of the world’s first cord and placental stem cell transplant from Lifebank.

Be Prepared for the Future of Medicine

1. The Power to Divide Into Specialized Cells

Placental blood and tissue are rich in mesenchymal stem cells (MSCs) and mesenchymal-like stem cells. MSCs have demonstrated unique regenerative capabilities because they secrete exosomes which contain many growth factors and other messages to regenerate into a wide variety of cells and tissues.7,8,9 Also, current research shows that MSCs may someday play a role in healing tissue damaged by disease.8 Banking placental blood and tissue, in addition to cord blood, permits greater capture of these powerful MSCs that may revolutionize regenerative medicine.10

2. Placental Blood and Tissue Stem Cells Are Packed With Potential

In July 2020, there were just over 1,000 registered clinical trials in the United States that were exploring the possible applications of MSCs.11,12 They include applications ranging from neurodegenerative and cardiac disorders to COVID-19 to cancers.11 By deciding to bank placental blood and tissue in addition to cord blood, a host of potential future applications for your stem cell collection emerge.

We hope that this information helps you understand the value of placental banking to complement cord blood banking! If you’re ready to add this to your stem cell banking package, call us at 877-543-3226 or visit our pricing and packages page.

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REFERENCES

  1. Parent’s Guide to Cord Blood Foundation. How much blood and stem cells does a typical umbilical cord hold? Accessed December 14, 2020. Available at: https://parentsguidecordblood.org/en/faqs/how-much-blood-and-stem-cells-does-a-typical-umbilical-cord-hold.
  2. Serikov V, Hounshell C, Larkin S, Green W, Ikeda H, Walter M, and Kuypers F. Human Term Placenta as a Source of Hematopoietic Cells. NCBI. 2009; 243(7):813-823. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389511/#:~:text=The%20placenta%20averaged%20a%20total,cord%20blood%20collection%20(10).
  3. Fajardo-Orduna G, Mayani H, et al. Human Mesenchymal Stem/Stromal Cells from Umbilical Cord Blood and Placenta Exhibit Similar Capacities to Promote Expansion of Hematopoietic Progenitor Cells in Vitro. Stem Cells International. November 9, 2017. Available at: https://www.hindawi.com/journals/sci/2017/6061729/.
  4. Dehn J, Spellman S, et al. Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR. Blood. 2019;134(12):924-934. Available at: https://ashpublications.org/blood/article/134/12/924/374909/Selection-of-unrelated-donors-and-cord-blood-units.
  5. Torlen J, Ringden O, et al. Low CD34 Dose is Associated with Poor Survival after Reduced-Intensity Conditioning Allogenic Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome. Biology of Blood and Marrow Transplantation. 2014;20(9):1418-1425. Available at: https://www.sciencedirect.com/science/article/pii/S108387911400319X.
  6. Data on File, Lifebank® Transplant List. Accessed December 15, 2020.
  7. Nature Research. Mesenchymal stem cells. Accessed December 15, 2020. Available at: https://www.nature.com/subjects/mesenchymal-stem-cells.
  8. Ullah I, Subbarao R, Rho G. Human mesenchymal stem cells – current trends and future prospective. Bioscience Reports. 2015; 35(2). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413017/.
  9. Iaquinta M, Mazzoni E, et al. Adult Stem Cells for Bone Regeneration and Repair. Frontiers in Cell and Developmental Biology. November 12, 2019. Available at: https://www.frontiersin.org/articles/10.3389/fcell.2019.00268/full.
  10. Zhao T, Feng S, et al. Emerging Role of Mesenchymal Stem Cell-derived Exosomes in Regenerative Medicine. Current Stem Cell Research & Therapy. 2019;14(6):482-494. Available at: https://www.ingentaconnect.com/content/ben/cscr/2019/00000014/00000006/art00006.
  11. Levy O, Kuai R, et al. Shattering barriers toward clinically meaningful MSC therapies. Science Advances. 2020;6(30). Available at: https://advances.sciencemag.org/content/6/30/eaba6884.
  12. gov. Active Mesenchymal Stem Cell Clinical Trials. Accessed on December 15, 2020. Available at: https://clinicaltrials.gov/ct2/results?term=mesenchymal+stem+cells&Search=Apply&recrs=b&recrs=a&recrs=f&recrs=d&recrs=m&age_v=&gndr=&type=&rslt=.